linkstream2 microblog

http://michorlab.dfci.harvard.edu/publications/Evolutionary%20Theory%20of%20Cancer,%20NYAS2009.pdf

http://www.cancer.gov/cancertopics/understandingcancer/cancergenomics/AllPages

http://asiasociety.org/new-york/visit/garden-court-caf%C3%A9

OLD: [[* 12p-3p (twtfss ~m), 12-2 summer , 212-570-5202 *]] x312

11-5p twtfss except summer

http://genome.cshlp.org/content/early/2013/01/02/gr.144600.112.abstract

QT:{{”
To demonstrate the promise of personalized genome analysis, the genome of HuRef was sequenced using the Life SOLiD™ platform. Nimbus Informatics performed the analytical work for this project and has made the resulting data available here, running entirely on the Amazon Cloud.
“}}
http://huref.nimbusinformatics.com

Nature. 2013 Aug 29;500(7464):593-7. doi: 10.1038/nature12364. Epub 2013 Jul 28.

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing.

Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G.

QT:{{”
…We report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing…. By weighted gene co-expression network analysis, we find that each developmental stage can be delineated concisely by a small number of functional modules of co-expressed genes. This result indicates a sequential order of transcriptional changes in pathways of cell cycle, gene regulation, translation and metabolism, acting in a step-wise fashion from cleavage to morula. Cross-species comparisons with mouse pre-implantation embryos reveal that the majority of human stage-specific modules (7 out of 9) are notably preserved, but developmental specificity and timing differ between human and mouse. Furthermore, we identify conserved key members (or hub genes) of the human and mouse networks.
“}}

A paper on C. elegans that’s very informative:
http://www.nature.com/ng/journal/v44/n3/full/ng.1050.html
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

Most notable of their findings is evidence of recent selective sweeps on chromosomes I, IV, V and (sort of) X. These sweeps have the potential to fix pseudogenes that might have been present at the time.

Young Investigator for Ekta Khurana

http://www.genomeweb.com/genomeweb-feature-eighth-annual-young-investigators

75 & Mad.
Open New Year’s Day
[[* 6a-10p *]]

[[* 8a-11p (mf), 9a-11p, 10a-9p (ss) *]]
(could be 10-10 for su)

Nice outer area for wine + good 4G there

http://viaquadronno.com/